T.J. Watt and the Steelers will make Jeff Driskel pay for their Week 16 frustrations.
Following a Week 15 shutout win on the road, the Titans return home for a cupcake matchup with Josh Johnson and the injury-ravaged Redskins.
The Buffalo defense was a major disappointment in Week 14, but it should bounce back strong against the injury-riddled Lions offense.
A Thursday game pitting Marcus Mariota against Cody Kessler is the perfect recipe for sacks and turnovers.
Seattle is the top streaming pick for Week 13, while Denver makes sense for those taking a multi-week approach.
The Cowboys shouldn't have much trouble disposing of Colt McCoy on Thanksgiving.
Following a surprisingly competitive performance in Kansas City last week, Chandler Jones and the Cardinals are rewarded with a cupcake matchup against the tanking Raiders in Week 11.
The upcoming slate provides a trio of first-rate streaming options, with the Chargers, Jets and Packers all in ideal spots to thrive.
Coming out of a bye week at full strength, Sean Lee and the Cowboys defense could be headed for an easy win over the Titans.
The New England defense has struggled in terms of points and yards allowed, but its tendency to create turnovers should lead to a big afternoon against the hapless Bills.
A home game against Buffalo makes the Colts our top Week 7 steaming pick, but the Broncos and Cardinals are also strong options in what should be a sloppy matchup.
The Packers are our top recommendation for a second time in three weeks, playing host to C.J. Beathard and the banged-up 49ers.
The surprisingly effective Tennessee defense should be in for a big day when it visits Buffalo this weekend.
The Bills are unlikely to repeat their Week 3 magic when they head to Lambeau Field on Sunday.
The Browns finally have the makings of a competent defense, led by Myles Garrett and Larry Ogunjobi. It all adds up to trouble for Sam Darnold and the Jets in Week 3.
Russell Wilson may end up running for his life in Week 2, bringing his one-man show to Chicago to face Khalil Mack and the Bears on Monday Night Football.
Sam Darnold will be pushed into the Lions' den without much help in his first NFL start.
The Lions shouldn't have much trouble disposing of Brett Hundley as two long-time rivals close out disappointing seasons.
Josh Norman and the Redskins will tee off on either Paxton Lynch or Brock Osweiler, after taking care of business against Blaine Gabbert on Sunday.
With Josh McCown out for the season, the Saints figure to feast on Bryce Petty in the Superdome this weekend.
The sickly Bills get some much-needed medicine in the form of Jacoby Brissett, who leads the NFL in sack rate and total sacks.
Josh Gordon's return may get the headlines, but the Cleveland offense still won't stand much of a chance against Joey Bosa, Melvin Ingram and Casey Hayward.
Vontaze Burfict and the Bengals get a prime matchup for the second straight week, this time playing host to the hapless Browns.
The Arizona defense isn't anything special this season, but it really doesn't need to be in Week 11 against Tom Savage.
The Lions are the obvious preference for a matchup with Cleveland, but Detroit is already owned in a lot of leagues, while the Titans and Bears are still widely available.
Patrick Peterson leads a well-rested Arizona defense out of a bye week to take on mistake-prone rookie C.J. Beathard in what could be his final start.
The Cincinnati defense shouldn't have much trouble against a struggling Indianapolis offense.
An underrated Buffalo defense spells trouble for the Buccaneers, particularly if Jameis Winston isn't healthy.
With Vic Beasley potentially returning from a hamstring injury, the Atlanta defense should overwhelm Jay Cutler and the struggling Miami offense.
The Eagles are this week's premium streaming selection thanks to a matchup with a one-dimensional Arizona offense.