Portland's Fanendo Adi looks to bust out of his summer slump Saturday against Real Salt Lake as the Timbers cling to the last playoff spot in the Western Conference.
FC Dallas rested most of their starters for Wednesday's 5-0 loss, which means Mauro Diaz and Co. are ready to break out Saturday against the lowly Fire.
Sebastian Giovinco was slated to play for Italy over the international break, which MLS plays through, but an adductor injury will keep him on the sidelines.
The Sounders could desperately use Clint Dempsey back in the lineup to pair with Obafemi Martins, but he remains questionable because of a hamstring injury.
Columbus' Kei Kamara is atop the goal expectancy list for MLS' two-game slate on Wednesday.
Obafemi Martins looks set to return for the Sounders this weekend, but he could be without strike partner Clint Dempsey.
David Villa has six goals in his last four games and will next face off against a Montreal side he's burned for three goals and one assist in two previous meetings.
David Villa is high up on the goal expectancy projection for Week 22, though there are a few players with better chances.
Major League Soccer's leading goal scorer, Kei Kamara, has a great matchup this weekend against a Chicago side that he scored against just days ago.
New York City FC's David Villa leads the goal expectancy list this week, and he's one of only two players projected to take at least five shots, with two on goal.
Blas Perez has always been known as a streaky scorer, and with two goals in Week 2, it may be time for fantasy owners to pounce.