Henrikh Mkhitaryan looks to be a player to own on Saturday's six-game slate, with Manchester United coming in as heavy favorites against Watford at Old Trafford.
Sunderland come into Tuesday's match without three starting defenders, which means Tottenham's Harry Kane could have a field day.
Paul Pogba has scored at least 40 fantasy points in three of his last four games, and a Monday matchup against West Ham should allow him to continue his solid form.
Manchester City's attack has understandably fallen off a bit without Sergio Aguero, but Leroy Sane may be the one to get them back on track Monday at Hull City.
With FanDuel introducing English Premier League contests this week, RotoWire's Andrew Laird looks into the key stats to focus on when building lineups.